ceesdekker No Further a Mystery
ceesdekker No Further a Mystery
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Human Rad51 filaments on double- and solitary-stranded DNA: correlating regular and irregular varieties with recombination function.
‘It absolutely was only a issue of selecting up a e-book on mobile biology and beginning to go through. I had originate from a entire world of ultra-superior vacuums, cryostats and quantum phenomena, and now I used to be Operating at home temperature with molecular biology kits.
Sculpting nano-electrodes by using a transmission electron beam for electrical and geometrical characterization of nanoparticles.
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Our investigation ranges through the biophysics of DNA to artificial cells and over and above. Remember to have a look beneath on the spectrum of our existing tasks.
‘To start with we checked out biological techniques that has a physical check out and acted on The premise of the resources we understood. It took a number of years prior to we commenced Doing the job more on the large biological difficulties. I then began to contact it nanobiology, a phrase that didn't exist at some time.
Nanopores symbolize a chic and adaptable Device to measure single molecules. We analysis novel detection modes with strong-state nanopores in addition to numerous methods to measure proteins with nanopores. Projects encompass the subsequent:
Knowledge essential procedures regulating the spatial and dynamic organisation with the DNA in Are living cells.
Presently, we also understood that it ought to be attainable to work with an individual semiconducting carbon nanotube for making a transistor — and we established out to make it. We stretched person semiconducting nanotubes throughout metallic electrodes and made use of the fundamental silicon substrate being a gate electrode, developing the basic three-terminal structure of the discipline-impact transistor (Fig.
Case in point (four) of bending configurations in 3D simulations of DNA rods on nanopores. A part of the membrane is shown in gray, cees dekker the rim of your pore is highlighted in purple, plus a 3D rendering from the movement with the DNA rod is shown.
2006, 1st demonstration of molecular sorting in a lab over a chip applying biomotors; discovery of nanobubbles in strong-condition nanopores; and initially estimate of electrokinetic energy conversion within a nanofluidic channel
2005, discovery of the mechanism of DNA uncoiling by topoisomerase enzymes; discovery of extensive-assortment conformational variations in Mre11/DNA fix complexes; and to start with power measurements over a DNA molecule in a nanopore
It had been a very intriguing time, all through which I obtained loads of assistance from Delft University of Know-how, where I was a professor at time, And that i begun several collaborations with molecular biologists. That assisted me understand quite a bit.’